The 2021 fantasy football season continues with our must-have Week 16 waiver wire pickups and fantasy football players to target! Anthony Aniano gives his in-depth fantasy football advice, breaking down some of his waiver wire adds to prioritize and free-agent pickups as we head into Week 16 of the fantasy football season. These players should be targets as injury replacements, bye-week fill-ins, streamers, sleepers, and general waiver wire targets to improve your fantasy football teams.