In this podcast series we focus on key topics in healthcare simulation education. The first several podcasts focus on the book, Comprehensive Healthcare Simulation: Mastery Learning in Health Professions Education, published by the Northwestern Simulation team in 2020. Dr. Jeffrey Barsuk leads the discussions by highlighting key issues about principles and practices of simulation-based mastery learning with chapter authors and book editors. Podcast listeners should feel free to reach out to the Northwestern Simulation team via email at: simed@northwestern.edu.