A central retinal artery occlusion is arguably one of the worst ocular events that can occur, given its extremely poor visual prognosis. As such, our efforts to find an effective treatment for CRAO have been extensive, but in many regards, inadequate. There are certain treatment options that we all learn in residency to try and halt a CRAO, but for the most part, many of these techniques are fairly unproven and don’t work so well. So what does actually work? And is the evidence for TPA strong enough that we should be routinely recommending it in appropriate cases? Dr. Rishi Gupta joins the podcast. Learn more about Dr. Gupta at https://rishiguptamd.com/about/Learn more about Dr. Gupta's books at https://rishiguptamd.com/textbooks/